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Size20 µg
Price185 €
SourceE. coli
Purity Confirmation> 95% by SDS-PAGE
Length [aa]109
Molecular Weight24.3 kDa
N Terminal SequenceSLGSL
Endotoxin Levels< 0.1 ng per ug of PDGF-BB
Biological ActivityThe biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).
Species ReactivityHuman
Buffer50mM acetic acid
ReconstitutionCentrifuge vial prior to opening. The lyophilized PDGF-BB should be reconstituted in 50mM acetic acid to a concentration not lower than 100μg/ml. For long term storage of reconstituted protein addition of carrier protein (e.g. BSA or HSA; 0.1%) is recommended.
Stability and StorageThe lyophilized PDGF-BB is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted PDGF-BB is best stored at -20°C to -70°C.
SynonymsPDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN=Becaplermin
DescriptionPDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).
Uniprot IDP01127
Protein RefSeqNP_002599.1
mRNA RefSeqNM_002608.2



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  2. Extracellular Vesicles Mediate Communication between Endothelial and Vascular Smooth Muscle Cells. M. Fontaine et al., Int J Mol Sci. 2022 Jan; 23(1): 331.
  3. Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. Rezzola S. et al., Diabetes. 2015 Jul;64(7):2581-92.

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