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|Purity Confirmation||> 98% by SDS-PAGE|
|Molecular Weight||15.5 kDa|
|N Terminal Sequence||APTSSSTK and MAPTSSST|
|Endotoxin Levels||< 0.1 ng per µg of IL-2|
|Biological Activity||The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/ml.|
|Buffer||50mM acetic acid|
|Reconstitution||The lyophilized IL-2 should be reconstituted in 50mM acetic acid to a concentration not less than 100µg/ml. This solution can be diluted into other buffered solutions or stored at -20°C for future use.|
|Stability and Storage||The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted IL-2 should be stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.|
|Synonyms||IL2; IL-2; TCGF; lymphokine|
|Description||IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.|
- Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. M. Schellhorn et al., Oncotarget. 2015 Nov 17; 6(36): 39342–39356.
- Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. M. Haustein et al., Biochem Pharmacol. 2014 Nov 15;92(2):312-25.
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