human VE-Statin/EGFL7

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Cat-Nr.100-433S
Size2 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]251
Molecular Weight27.4 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityData not available.
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening!
SynonymsEGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2, NOTCH4-like protein,
DescriptionEGF-L7 (Epidermal Growth Factor Like Protein 7, Multiple EGF Like Domains Protein 7, VE Statin) is a multi-domain protein containing two EGF like domains and one EMI domain. It is expressed almost exclusively in endothelial cells and functions to promote normal development of the vascular system, particularly tubulogenesis. EGF-L7 is capable of antagonistic binding to Notch receptors resulting in the inhibition of Notch signaling in HUVEC and neural stem cells. In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF-L7 can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaB activation. Additionally, EGF-L7 can chemoattract endothelial cells and bind to the extracellular matrix. The overexpression of EGF-L7 is observed in various cancers, and is generally correlated with increased metastasis and a poor prognosis.  Recombinant human EGF-L7 is a 27.4 kDa protein containing 251 amino acid residues.
Protein SequenceMYRPGRRVCA VRAHGDPVSE SFVQRVYQPF LTTCDGHRAC STYRTIYRTA YRRSPGLAPA RPRYACCPGW KRTSGLPGAC GAAICQPPCR NGGSCVQPGR CRCPAGWRGD TCQSDVDECS ARRGGCPQRC VNTAGSYWCQ CWEGHSLSAD GTLCVPKGGP PRVAPNPTGV DSAMKEEVQR LQSRVDLLEE KLQLVLAPLH SLASQALEHG LPDPGSLLVH SFQQLGRIDS LS
Uniprot IDQ9UHF1
Protein RefSeqNP_057299.1
mRNA RefSeqNM_016215.4

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