Human Thymosin-beta4

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Cat-Nr.100-428
Size100 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 95% by SDS-PAGE & HPLC analyses
Length [aa]45
Molecular Weight5.2 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityPretreatment of primary lung fibroblasts with recombinant Thymosin-β4, using a concentration of 0.5 - 10 μg/ml, produces a protective effect against hydrogen peroxide induced cell death.
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening!
SynonymsHematopietic system regulatory peptide, Seraspenide, TMSB4X, TMSB4
DescriptionThymosin-β4 is a small, actin-sequestering protein belonging to the thymosin-β family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin’s polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, Thymosin-β4 has also been shown to be synthesized by cells unrelated to the reticuloendothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found Thymosin-β4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the s-phase. Recombinant Human Thymosin-β4 is a 5.2 kDa glycoprotein containing 45 amino acid residues.
Protein SequenceRMSDKPDMAE IEKFDKSKLK KTETQEKNPL PSKETIEQEK QAGES
Uniprot IDP62328
Protein RefSeqNP_066932.1
mRNA RefSeqNM_021109.3

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