human BMP-10

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Cat-Nr.100-405
Size10 µg
Price170 €
SourceHEK293 cells
Formulationlyophilized
Purity Confirmation>95% by SDS-PAGE & HPLC analysis
Length [aa]108
Molecular Weight24.4 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 4.0-6.0 ng/ml.
Species ReactivityHuman
SynonymsBMP-10, Bone morphogenic protein 10
DescriptionBone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.&nbsp; It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes.&nbsp; BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.&nbsp; Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
Protein SequenceNAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR
Uniprot IDO95393
Protein RefSeqNP_055297.1
mRNA RefSeqNM_014482.1

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