Human GDF-5
Slide this table
| Cat-Nr. | 100-389 |
| Size | 50 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & RP-HPLC |
| Length [aa] | 120 |
| Molecular Weight | 26.8 kDa |
| Biological Activity | The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml. |
| Species Reactivity | Human |
| Synonyms | GDF5; OS5; LAP4; BMP14; CDMP1; SYNS2 |
| Description | GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. GDF-5 produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 120 amino acids and having a total molecular mass of 26.8 Dalton. |
| Protein Sequence | APSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR |
| Uniprot ID | P43026 |
| Protein RefSeq | NP_000548 |
| mRNA RefSeq | NM_000557 |
All prices plus VAT + possible delivery charges