Human GDF-5

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Cat-Nr.100-389
Size50 µg
Price180 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & RP-HPLC
Length [aa]120
Molecular Weight26.8 kDa
Biological ActivityThe ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
Species ReactivityHuman
SynonymsGDF5; OS5; LAP4; BMP14; CDMP1; SYNS2
DescriptionGDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. GDF-5 produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 120 amino acids and having a total molecular mass of 26.8 Dalton.
Protein SequenceAPSATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Uniprot IDP43026
Protein RefSeqNP_000548
mRNA RefSeqNM_000557

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