Human Relaxin-3

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Cat-Nr.100-356S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]51
Molecular Weight5.5 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityData not available.
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening!
SynonymsRLN3; H3; RXN3; ZINS4; insl7
DescriptionRelaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.
Protein SequenceA-chain: DVLAGLSSS CCKWGCSKSE ISSLC; B-chain: RAAPYGVRL CGREFIRAVI FTCGGSRW
Uniprot IDQ8WXF3
Protein RefSeqNP_543140.1
mRNA RefSeqNM_080864

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