Human Endostatin

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Cat-Nr.100-334
Size100 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation98% by SDS-PAGE & HPLC analyses
Length [aa]184
Molecular Weight20.2 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityMeasured by its ability to inhibit HUVEC migration.
Species ReactivityHuman
SynonymsCOL18A1; KS; KNO; KNO1
DescriptionEndostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues.
Protein SequenceMHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK
Uniprot IDP39060
Protein RefSeqNP_085059
mRNA RefSeqNM_030582

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