Human Betacellulin

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Cat-Nr.100-332S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation >98% by SDS-PAGE & HPLC analyses
Length [aa]80
Molecular Weight9.0 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10^7 units/mg.
Species ReactivityMouse, Human
ReconstitutionCentrifuge the vial prior to opening!
SynonymsBTC
DescriptionBetacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Protein SequenceDGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
Uniprot IDP35070
Protein RefSeqNP_001720
mRNA RefSeqNM_001729

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