Human BMP-4

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Cat-Nr.100-326H
Size10 µg
Price160 €
SourceHEK293 cells
Formulationlyophilized
Purity Confirmation>95% by SDS-PAGE
Length [aa]113
Molecular Weight34.0 kDa
Biological ActivityThe specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Species ReactivityHuman, Mouse, Rat
Buffer2XS PBS + 6% EtOH
Stability and StorageLyophilized BMP4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
SynonymsBMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
DescriptionBone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
Protein SequenceHHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
Uniprot IDP12644
Protein RefSeqNP_001193
mRNA RefSeqNM_001202

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