Human BMP-4

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Cat-Nr.100-326H
Size5 µg
Price180 €
SourceHeLa cells
Formulationlyophilized
Purity Confirmation≥ 97% by SDS-PAGE gel and HPLC analyses.
Length [aa]113
Molecular Weight34.0 kDa
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
Species ReactivityHuman, Mouse, Rat
SynonymsBMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
DescriptionBone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein.
Protein SequenceHHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
Uniprot IDP12644
Protein RefSeqNP_001193
mRNA RefSeqNM_001202

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