Human Activin-A

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Size10 µg
Price199 €
SourceInsect cells
Purity Confirmation> 97% by SDS-PAGE & HPLC analyses
Length [aa]116
Molecular Weight26.0 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityThe ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Species ReactivityChicken, Dog, Frog, Mouse, Rat, Human, Leech
Buffer10 mM Sodium Citrate, pH 3.0
DescriptionActivin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
Uniprot IDP08476
Protein RefSeqNP_002183.1
mRNA RefSeqNM_002192.2

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