Human IFN-lambda1 (IL-29)

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Cat-Nr.100-193S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]178
Molecular Weight19.8 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Species ReactivityHuman, Monkey
SynonymsIL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B
DescriptionIFN lambda-1,-2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I interferons (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
Protein SequencePTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Uniprot IDQ8IU54
Protein RefSeqNP_742152.1
mRNA RefSeqNM_172140.1

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