Human VAP-1

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Cat-Nr.100-141
Size10 µg
Price170 €
SourceCHO cells
Formulationlyophilized
Purity Confirmation >98% by SDS-PAGE & HPLC analysis
Length [aa]737
Molecular Weight81.8 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityMeasured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity >16 pMoles/min/µg of VAP-1.
Species ReactivityHuman
ReconstitutionCentrifuge the vial prior to opening!
SynonymsAOC3; HPAO; SSAO; VAP1; VAP-1
DescriptionVAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaqui oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. VAP-1 can catalyze the oxidative deamination of low molecular weight amines, and plays an important role in the migration of lymphocytes to inflamed tissue. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor.
Protein SequenceGRGGDGGEPS QLPHCPSVSP SAQPWTHPGQ SQLFADLSRE ELTAVMRFLT QRLGPGLVDA AQARPSDNCV FSVELQLPPK AAALAHLDRG SPPPAREALA IVFFGRQPQP NVSELVVGPL PHPSYMRDVT VERHGGPLPY HRRPVLFQEY LDIDQMIFNR ELPQASGLLH HCCFYKHRGR NLVTMTTAPR GLQSGDRATW FGLYYNISGA GFFLHHVGLE LLVNHKALDP AR
Uniprot IDQ16853
Protein RefSeqNP_003725.1
mRNA RefSeqNM_003734.3

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