Human TPO

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Cat-Nr.100-109
Size10 µg
Price199 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE
Length [aa]174
Molecular Weight18.6 kDa
Biological ActivityThe ED50 as determined by the dose-dependant stimulation of MO7e cells is < 1 ng/ml (1x106 units/mg).
Species ReactivityHuman
SynonymsThrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
DescriptionTPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Protein SequenceSPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Uniprot IDP40225
Protein RefSeqNP_000451.1
mRNA RefSeqNM_000460.2

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