Human NAP-2 (CXCL7)

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Cat-Nr.100-082S
Size2 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analysis
Length [aa]70
Molecular Weight7.6 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to chemoattract human neutrophils using a concentration range of 1.0-10.0 ng/ml.
Species ReactivityHamster, Human, Mouse
ReconstitutionCentrifuge the vial prior to opening!
SynonymsCXCL7, NAP1L4; NAP2; NAP2L; hNAP2; NAP1L4b
DescriptionNAP-2 is a CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is produced in leukocytes by enzymatic processing of a precursor called platelet basic protein (PBP). NAP-2 chemoattracts and activates neutrophils. Recombinant human NAP-2 protein is a 7.6 kDa protein containing 70 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines, and also including the “ELR” motif common to CXC chemokines that bind to CXCR1 and CXCR2.
Protein SequenceAELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESA
Uniprot IDP02775
Protein RefSeqNP_002695.1
mRNA RefSeqNM_002704.3

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