Human MIP-4 (CCL18)

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Cat-Nr.100-080
Size10 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]68
Molecular Weight7.8 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityAssay #1: Determined by its ability to chemoattract human T lymphocytes using a concentration of 1.0 - 10.0 ng/ml. Assay #2: Determined by its ability to chemoattract human iDCs using a concentration of 1.0 - 10.0 ng/ml.
Species ReactivityHuman, Mouse, Bacteria
ReconstitutionCentrifuge the vial prior to opening!
Stability and StorageFor extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % HSA or 0.1% BSA) and store in working aliquots at -20 °C to -80 °C. Lyophilized MIP-4 although stable at room temperature for 3 weeks, should be stored desiccated below -20 °C. Upon reconstitution MIP-4 can be stored at 4 °C between 2-7 days and for future use below -20 °C.
SynonymsMacrophage Inflammatory Protein-4, CCL18, PARC, DC-CK1, AMAC-1
DescriptionMIP-4 is a CC chemokine that is expressed in lymph nodes, lungs, placenta and bone marrow. MIP-4’s primary receptor is unknown. MIP-4 chemoattracts lymphocytes, and has been shown to exert activity on both CD4+and CD8+ T cells. Recombinant human MIP-4 is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Protein SequenceQVGTNKELC CLVYTSWQIP QKFLVDYSET SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA
Uniprot IDP55774
Protein RefSeqNP_002979
mRNA RefSeqNM_002988

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