Human Midkine

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Cat-Nr.100-071S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]123
Molecular Weight13.4 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.
Species ReactivityMouse, Pig, Shark, Human, Hagfish, Squid
ReconstitutionCentrifuge the vial prior to opening!
SynonymsMDK; MK; NEGF2
DescriptionMidkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.
Protein SequenceVAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
Uniprot IDP21741
Protein RefSeqNP_001012333
mRNA RefSeqNM_001012333

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