Human Flt-3 Ligand

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Cat-Nr.100-026-SC
Size50 µg
Price375 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 95% by SDS-PAGE and RP-HPLC
Length [aa]155
Molecular Weight17.6 kDa
Biological ActivityThe ED50 range=0.5-1.0 ng/ml corresponding to a specific activity of 1-2MUnits/mg, calculated by the dose-dependant stimulation of the proliferation of human OCMI-AML5 cells.
Species ReactivityHuman
SynonymsFLT3; FLK2; STK1; CD135; FLK-2
DescriptionFlt3-ligand (flk2-ligand) stimulates the proliferation and colony formation of certain BM precursor cells including CD34+ cells. Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.
Protein SequenceTQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
Uniprot IDP49771
Protein RefSeqNP_001450.2
mRNA RefSeqNM_001459.3

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