Human Eotaxin-2 (CCL24)
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| Cat-Nr. | 100-013 |
| Size | 20 µg |
| Price | 199 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 78 |
| Molecular Weight | 8.8 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml. |
| Species Reactivity | Mouse, Human, Bacteria |
| Synonyms | CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24 |
| Description | Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation). Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues. |
| Protein Sequence | VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA |
| Uniprot ID | O00175 |
| Protein RefSeq | NP_002982.2 |
| mRNA RefSeq | NM_002991 |
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