Human Eotaxin-2 (CCL24)

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Cat-Nr.100-013
Size20 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]78
Molecular Weight8.8 kDa
Endotoxin Levels< 0.1 ng /mg of protein (<1EU/mg).
Biological ActivityDetermined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml.
Species ReactivityMouse, Human, Bacteria
ReconstitutionCentrifuge the vial prior to opening!
SynonymsCCL24; Ckb-6; MPIF2; MPIF-2; SCYA24
DescriptionEotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation). Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues.
Protein SequenceVVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA
Uniprot IDO00175
Protein RefSeqNP_002982.2
mRNA RefSeqNM_002991

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