Human ENA-78 (5-78aa)/ (CXCL5)

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Cat-Nr.100-011
Size20 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE
Length [aa]74
Molecular Weight8.0 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to chemoattract human peripheral blood neutrophils using a concentration of 5.0-10.0 ng/ml.
Species ReactivityHamster, Human, Bacteria
SynonymsCXCL5; SCYB5; ENA-78
DescriptionENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is an 8.0 kDa protein consisting of 74 amino acid residues.
Protein SequenceAAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN
Uniprot IDP42830
Protein RefSeqNP_002985.1
mRNA RefSeqNM_002994.3

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