Human CNTF

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Cat-Nr.100-007S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation98% by SDS-PAGE & HPLC analyses
Length [aa]199
Molecular Weight22.7 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.
Species ReactivityHamster, Mouse, Rat, Frog, Human
Buffer 5 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl
SynonymsCNTF; HCNTF
DescriptionCNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant human CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion
Protein SequenceMAFTEHSPLT PHRRDLCSRS IWLARKLRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Uniprot IDP26441
Protein RefSeqNP_000605
mRNA RefSeqNM_000614

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