Rat Flt-3 Ligand

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Cat-Nr.R20-076
Size10 µg
Price190 €
CategoryCytokines & Growth Factors
SourceE. coli
Species ReactivityRat
Formulationlyophilized
Purity Confirmation≥ 98% by SDS-PAGE gel and HPLC analyses
Length [aa]162
Molecular Weight18.3 kDa
SynonymsFms‐related tyrosine kinase 3 ligand, Flt3L
DescriptionFlt3‐Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3‐Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3‐Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3‐Ligand exerts no activity on mast cells. Multiple isoforms of Flt3‐Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane‐bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Rat Flt3‐Ligand is a soluble 18.3 kDa protein consisting of 162 amino acid residues.
Protein SequenceTPDCYFSHSP ISSNFHMRIS ELTDYLLKDY PVTVAINLQD EKHCKALWSL FLAHRWIEQL KTVAGSKMQK LLEDVNTEIH FVTSCTFQPL PECLRFVQTN ISHLLQDTCS QLLALKPCIG KACQNFSRCL EVQCQPDSST LLPPESPGAL GATELPKPLP RQ
Uniprot IDReviewed Data Unavailable
Protein RefSeqNP_001094292.1
mRNA RefSeqNM_001100822.3

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