Human sIL-15 Receptor alpha Fc
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| Cat-Nr. | S01-083 |
| Size | 100 µg |
| Price | 199 € |
| Source | Insect cells |
| Label | Fc-tag |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 408 |
| Molecular Weight | 44.4 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (< 1 EU/µg) |
| Biological Activity | Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15. |
| Species Reactivity | Human |
| Synonyms | soluble Interleukin‐15 receptor subunit alpha, soluble IL‐15RA, CD215 |
| Description | IL‐15 signaling is an important factor in proliferating, activating, and immunomodulating primarily T cells. IL‐15R α is an IL‐15 specific, single pass membrane receptor which complexes with IL‐2R β and IL‐2R γ to form a high affinity IL‐15 receptor. Additionally, the IL‐15/IL‐15R complex is capable of binding to IL‐2 β/γ receptors on other cells, therefore enabling IL‐15 to indirectly activate cells expressing IL‐2 β/γ receptors. A soluble form of IL‐15 receptor α is naturally produced by proteolytic cleavage of the membrane‐bound precursor. This naturally occurring soluble form can act as a modulator of IL‐15 signaling through the inhibition of IL‐15 receptor binding. Recombinant Human sIL‐15 Receptor α Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL‐15R α fused to the Fc portion of human IgG. Due to glycosylation, it migrates at an apparent molecular weight of 50‐60 kDa, under reducing conditions. |
| Protein Sequence | ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK |
| Uniprot ID | Q13261 |
| Protein RefSeq | NP_001230468.1 |
| mRNA RefSeq | NM_001243539.2 |
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