Human TRAIL R-1/DR4, soluble

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Cat-Nr.S01-035S
Size10 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]215
Molecular Weight22.7 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityMeasured by its ability to inhibit apoptosis in LN-18 cells.  The expected ED50 for this effect is 0.4 -0.5 µg/ml.
Species ReactivityHuman
SynonymsTNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
DescriptionTRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Protein SequenceMSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN
Uniprot IDO00220
Protein RefSeqNP_003835.3
mRNA RefSeqNM_003844.3

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