Rat GDNF (Animal Free)
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Cat-Nr. | R20-047S-AF |
Size | 2 µg |
Price | 135 € |
Source | E. coli |
Formulation | lyophilized |
Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Length [aa] | 135 |
Molecular Weight | 15 kDa |
Endotoxin Levels | < 0.01 ng/ug of protein (< 0.1 EU/ug) |
Biological Activity | Determined by its ability to stimulate the proliferation of rat C6 cells. |
Synonyms | Gdnf |
Description | GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa. |
Protein Sequence | MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI |
Uniprot ID | Q07731 |
Protein RefSeq | NP_062012.1 |
mRNA RefSeq | NM_019139 |
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