Human/Murine/Rat BMP-2 (Animal Free)
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| Cat-Nr. | 200-002S-AF |
| Size | 2 µg |
| Price | 135 € |
| Source | E. coli |
| Formulation | lyophilized |
| Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 115 |
| Molecular Weight | 26.0 kDa |
| N Terminal Sequence | MQAKHKQ |
| Endotoxin Levels | Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) |
| Biological Activity | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml. |
| Species Reactivity | Human, Mouse |
| Synonyms | bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 |
| Description | Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein. |
| Protein Sequence | MQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR |
| Uniprot ID | P12643 |
| Protein RefSeq | NP_001191 |
| mRNA RefSeq | NM_001200 |
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