Human IFN beta (Animal Free)

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Cat-Nr.100-191S-AF
Size5 µg
Price135 €
SourceE. coli
Formulationlyophilized
Purity Confirmation≥ 95% by SDS-PAGE gel and HPLC analyses.
Length [aa]166
Molecular Weight20 kDa
Endotoxin Levels< 0.01 ng/µg of protein (< 0.1 EU/µg)
Biological ActivityDetermined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 106 units/mg.
Species ReactivityHuman, Mouse
SynonymsIFNB1; IFB; IFF; IFNB
DescriptionProteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections.  They also affect cell proliferation and modulate immune responses.  Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β.  Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens.  IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues. 
Protein SequenceMSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
Uniprot IDP01574
Protein RefSeqNP_002167.1
mRNA RefSeqNM_002176

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