Human GDF-3 (Animal Free)
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Cat-Nr. | 100-179S-AF |
Size | 5 µg |
Price | 135 € |
Source | E. coli |
Formulation | lyophilized |
Purity Confirmation | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
Length [aa] | 114 |
Molecular Weight | 26 kDa |
Endotoxin Levels | < 0.01 ng/ug of protein (< 0.1 EU/ug) |
Biological Activity | Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml. |
Synonyms | GDF3; KFS3; MCOP7; MCOPCB6 |
Description | GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia that characterizes Type 2 diabetes. Recombinant Human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains. |
Protein Sequence | AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG |
Uniprot ID | Q9NR23 |
Protein RefSeq | NP_065685.1 |
mRNA RefSeq | NM_020634 |
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