Human BMP-13 / CDMP-2 (Animal Free)

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Cat-Nr.100-137-AF
Size50 µg
Price230 €
SourceE. coli
Formulationlyophilized
Purity Confirmation≥ 95% by SDS-PAGE gel and HPLC analyses.
Length [aa]120
Molecular Weight27.0 kDa
Endotoxin LevelsEndotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.0-3.0 µg/ml.
Species ReactivityMouse, Human
SynonymsGDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6
DescriptionBMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino-acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. 
Protein SequenceTAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
Uniprot IDP43028
Protein RefSeqNP_038554.1
mRNA RefSeqNM_013526.1

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