Human MIP-1 alpha (CCL3, Animal Free)

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Cat-Nr.100-073-AF
Size20 µg
Price230 €
SourceE. coli
Formulationlyophilized
Purity Confirmation≥ 98% by SDS-PAGE gel and HPLC analyses.
Length [aa]70
Molecular Weight7.8 kDa
Endotoxin Levels< 0.01 ng/µg of protein (< 0.1 EU/µg)
Biological ActivityDetermined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.
Species ReactivityCow, Frog, Hamster, Monkey, Mouse, Rat, Human, Leech
SynonymsCCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
DescriptionBoth MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1α is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Protein SequenceASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Uniprot IDP10147
Protein RefSeqNP_002974.1
mRNA RefSeqNM_002983

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