Human/Murine FGF-8B (Animal Free)

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Cat-Nr.100-020-AF
Size25 µg
Price230 €
SourceE. coli
Formulationlyophilized
Purity Confirmation≥ 97% by SDS-PAGE gel and HPLC analyses.
Length [aa]193
Molecular Weight22.4 kDa
Endotoxin Levels< 0.01 ng/ug of protein (< 0.1 EU/ug)
Biological ActivityDetermined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 2.0-4.0 ng/ml.
SynonymsFGF8; AIGF; KAL6; FGF-8; HBGF-8
DescriptionFGF-8 (FGF-8b) is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8A, FGF-8B, FGF-8E and FGF-8F. The human and murine FGF-8A and B are identical, unlike human and mouse FGF-8E and F, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. Recombinant Human/Murine FGF-8 (FGF-8b) is a 22.5 kDa protein consisting of 194 amino acid residues.
Protein SequenceMQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Uniprot IDP55075
Protein RefSeqNP_149355
mRNA RefSeqNM_033165

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