Human Eotaxin-3 (CCL26)

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Cat-Nr.100-014S
Size5 µg
Price75 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 98% by SDS-PAGE & HPLC analyses
Length [aa]71
Molecular Weight8.4 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2 µg/ml.
Species ReactivityHuman
SynonymsCCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
DescriptionEotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Protein SequenceTRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Uniprot IDQ9Y258
Protein RefSeqNP_006063
mRNA RefSeqNM_006072

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