Human BAFF (Animal Free)

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Cat-Nr.100-002-AF
Size20 µg
Price230 €
SourceE. coli
Formulationlyophilized
Purity Confirmation≥ 95% by SDS-PAGE gel and HPLC analyses.
Length [aa]153
Molecular Weight17.0 kDa
Endotoxin Levels< 0.01 ng/µg of protein (<0.1EU/µg)
Biological ActivityDetermined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.
Species ReactivityHuman
SynonymsTNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF22
DescriptionBAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.
Protein SequenceAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Uniprot IDQ9Y275
Protein RefSeqNP_006564.1
mRNA RefSeqNM_006573.4

Reference

  1. Increased B Cell-Activating Factor Promotes Tumor Invasion and Metastasis in Human Pancreatic Cancer. Mitsuhito Koizumi et al., PLoS One. 2013; 8(8): e71367.

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