Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSFß, pluripoietin
> 98% by SDS-PAGE & HPLC analyses
Determined by its ability to stimulate the proliferation of mouse NFS-60 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
MKKIPLLTVS SLPPSLPLPR SFLLKSLEQV RKIQARNTEL LEQLCA
TYKL CHPEELVLFG HSLGIPKASL SSCSSQALQQ TKCLSQLHSG L
FLYQGLLQA LAGISSELAP TLDMLHLDVD NFATTIWQQM ESLGVAP
TVQ PTQSTMPIFT SAFQRRAGGV LVTSYLQSFL ETAHHALHHL PR
G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Recombinant rat G-CSF is a 21.6 kDa protein consisting of 196 amino acid residues.
NCBI Gene ID: