Description / human NGF-beta protein
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
More Information
| Size | 20 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analysis |
| Length [aa] | 240 |
| Molecular Weight | 13.5 kDa |
| Species Reactivity | Chicken, Hamster, Mouse, Rat, Human, Leech |
| Formulation | lyophilized |
| Protein Sequence | SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA |
| Synonyms | NGF; NGFB; HSAN5; Beta-NGF |
| Uniprot ID | P01138 |
| Protein RefSeq | NP_002497.2 |
| mRNA RefSeq | NM_002506 |