Description / anti-human NGF-beta monoclonal antibody
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 14 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
More Information
| Size | 500 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced in mice using highly pure (>98%) recombinant human beta-NGF as the immunizing antigen. This IgG2bK antibody was purified from cell culture by Protein G affinity chromatography. |
| Antigen | Recombinant Human NGF-beta |
| Application | ELISA, N, WB, IHC |
| Synonyms | NGF; NGFB; HSAN5; Beta-NGF |
| Uniprot ID | P01138 |
| Protein RefSeq | NP_002497.2 |
| mRNA RefSeq | NM_002506 |