Description / mouse IFN gamma protein
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
More Information
| Size | 100 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 134 |
| Molecular Weight | 15.6 kDa |
| Species Reactivity | Rabbit, Rat, Mouse, Human, Cow |
| Formulation | lyophilized |
| Protein Sequence | MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC |
| Synonyms | Ifng; Ifg; IFN-g |
| Uniprot ID | P01580 |
| Protein RefSeq | NP_032363 |
| mRNA RefSeq | NM_008337 |