Description / human IFN beta (Animal Free) protein
Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues.
More Information
| Size | 5 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 106 units/mg. |
| Purity Confirmation | ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Length [aa] | 166 |
| Molecular Weight | 20 kDa |
| Species Reactivity | Human, Mouse |
| Formulation | lyophilized |
| Protein Sequence | MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN |
| Synonyms | IFNB1; IFB; IFF; IFNB |
| Uniprot ID | P01574 |
| Protein RefSeq | NP_002167.1 |
| mRNA RefSeq | NM_002176 |