Description / anti-human IFN beta polyclonal antibody
Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.
More Information
| Size | 100 µg |
|---|---|
| Source | Rabbit |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of rabbits immunized with highly pure recombinant human CCM-2 (Cerebral cavernous malformations 2 protein; aa: Met1-Ala444; SwissProt: #Q9BSQ5) as the immunizing antigen. Anti-human CCM-2 was purified by affinity chromatography with imm |
| Antigen | Recombinant human IFN-beta |
| Application | ELISA, WB, N |
| Synonyms | IFNB1; IFB; IFF; IFNB |
| Uniprot ID | P01574 |
| Protein RefSeq | NP_002167.1 |
| mRNA RefSeq | NM_002176 |