Description / Eotaxin-3 (CCL26)
Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
More Information
Size | 20 µg |
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Source | E. coli |
Biological Activity | Determined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2 µg/ml. |
Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
Length [aa] | 71 |
Molecular Weight | 8.4 kDa |
Species Reactivity | Human |
Formulation | lyophilized |
Protein Sequence | TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L |
Synonyms | CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha |
Uniprot ID | Q9Y258 |
Protein RefSeq | NP_006063 |
mRNA RefSeq | NM_006072 |