Endothelin-1/ET-1 Human 5 µg

In stock

Cat-Nr.
200-017S
Size
5 µg
  €190.00

Description / Endothelin-1/ET-1

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.

More Information

Size 5 µg
Source E. coli
Purity Confirmation > 98% by SDS-PAGE & visualized Coomassie stain
Length [aa] 204
Molecular Weight 26.0 kDa
Species Reactivity Human
Formulation lyophilized from PBS
Buffer PBS
Protein Sequence MAPETAVLGA ELSAVGENGG EKPTPSPPWR LRRSKRCSCS SLMDKECVYF CHLDIIWVNT PEHVVPYGLG SPRSKRALEN LLPTKATDRE NRCQCASQKD KKCWNFCQAG KELRAEDIME KDWNNHKKGK DCSKLGKKCI YQQLVRGRKI RRSSEEHLRQ TRSETMRNSV KSSFHDPKLK GKPSRERYVT HNRAHWLEHH HHHH
Antigen Recombinant Human Endothelin-1
Synonyms Preproendothelin-1, PPET-1, ET-1, EDN1
Uniprot ID P05305
Protein RefSeq NP_001946.3
mRNA RefSeq NM_01955.4

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