Description / Endostatin
Endostatin is a naturally occurring 20 kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant human Endostatin is a 20.2 kDa protein consisting 184 amino acid residues.
More Information
| Size | 100 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Measured by its ability to inhibit HUVEC migration. |
| Purity Confirmation | 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 184 |
| Molecular Weight | 20.2 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK |
| Synonyms | COL18A1; KS; KNO; KNO1 |
| Uniprot ID | P39060 |
| Protein RefSeq | NP_085059 |
| mRNA RefSeq | NM_030582 |