Endostatin Anti-Human 100 µg

In stock

Cat-Nr.
102-P226
Size
100 µg
  €271.00

Description / Endostatin

Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis, is an approximately 181 amino acid (aa), 20 kDa proteolytic fragment of the C-terminal non collagenous domain of type XVIII collagen. It is produced and/or trimmed by metalloproteinases such as MMP2 and MMP9, and cathepsins S, B and L. The Nterminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains three zinc binding sites that are thought to be critical for its anti-endothelial and ant-itumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Human Endostatin shares 84-87% aa sequence identity with mouse, rat, bovine and equine Endostatin. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to downregulate angiogenesis by blocking VEGF-induced endothelial cell migration. It alters the effect of FGF basic on adhesion and cell motility. Endostatin can interact with Transglutaminase 2, heparin, and integrins α5β1 and αv β3, all of which may be secreted by, or expressed on, endothelial cells, and can influence adhesion or migration.

More Information

Size 100 µg
Source Rabbit
Clone Nr. Rabbit IgG
Species Reactivity Human
Formulation lyophilized from PBS
Buffer PBS
Reconstitution Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and Storage The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Preparation Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant Endostatin. Anti-Human Endostatin specific antibody was purified by affinity chromatography employing immobilized Endostatin matrix.
Antigen Recombinant Human Endostatin
Application ELISA, WB
Synonyms COL18A1; KS; KNO; KNO1
Uniprot ID P39060
Protein RefSeq NP_085059
mRNA RefSeq NM_030582

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