E-Selectin Human 10 µg

In stock

Cat-Nr.
100-410S
Size
10 µg
  €112.00

Description / E-Selectin

Selectins are a family of calcium-dependent type 1 transmembrane proteins. Endothelial (E)-selectin is a heavily glycosylated transmembrane protein expressed by activated endothelial cells in microvascular linings. E-selectin, along with P-selectin and L-selectin, initiate recruitment of circulating leukocytes from blood to sites of inflammation in the vascular lining through interaction with specific cell surface associated carbohydrate determinants. E-selectin consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain. Recombinant human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions.

More Information

Size 10 µg
Source CHO cells
Biological Activity Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line.
Purity Confirmation >95% by SDS-PAGE & HPLC analysis
Length [aa] 535
Molecular Weight 58.6 kDa
Species Reactivity Human
Formulation lyophilized
Protein Sequence WSYNTSTEAM TYDEASAYCQ QRYTHLVAIQ NKEEIEYLNS ILSYSPSYYW IGIRKVNNVW VWVGTQKPLT EEAKNWAPGE PNNRQKDEDC VEIYIKREKD VGMWNDERCS KKKLALCYTA ACTNTSCSGH GECVETINNY TCKCDPGFSG LKCEQIVNCT ALESPEHGSL VCSHPLGNFS YNSSCSISCD RGYLPSSMET MQCMSSGEWS APIPACNVVE CDAVTNPANG FV
Synonyms Endothelial leukocyte adhesion molecule 1, ELAM1, CD62E, SELE
Uniprot ID P16581
Protein RefSeq NP_000441.2
mRNA RefSeq NM_000450.2

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