Description / CXCR4
CXCR4, also known as fusin, is a 7TM G protein-linked chemokine receptor. CXCR4 is expressed on B cells, monocytes, CD4+ T cells, colonic epithelial cells, and astrocytes and binds SDF1/ CXCL12. CXCR4 is upregulated on mammary tumors. CXCR4, in cooperation with CD134 and heparan sulfate proteoglycans, functions as a coreceptor for feline immunodeficiency virus (FIV) entry into cells. Feline CXCR4 shares 97%, 95%, 88%, and 90% aa sequence identity with canine, human, mouse, and rat CXCR4, respectively.
More Information
| Size | 200 µg |
|---|---|
| Source | Rabbit |
| Biological Activity | Western Blot: Use 2-5 µg/ml |
| Clone Nr. | Rabbit IgG |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% |
| Preparation | Purified from sera of rabbits immunized with highly pure recombinant human CXCR4 fusion protein [N-terminal and extracellular loops] produced in E. coli. |
| Antigen | Recombinant human CXCR4 fusion protein [N-terminal and loops] |
| Application | WB, E |
| Synonyms | CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E |
| Uniprot ID | P61073 |
| Protein RefSeq | NP_001008540.1 |
| mRNA RefSeq | NM_001008540.1 |