Description / human WISP-3 protein
WISP-3 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is predominantly expressed in the adult kidney, testis and fetal kidney and weaker expression in placenta, ovary, prostate, small intestine, and skeletally-derived cells. WISP-3 is required for normal postnatal skeletal growth and cartilage homeostasis. Human WISP-3 is a 36.8 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cystine knot-like (CTCK) domain.
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| Size | 20 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 0.2-0.3 µg/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analysis |
| Length [aa] | 331 |
| Molecular Weight | 36.8 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | TGPLDTTPEG RPGEVSDAPQ RKQFCHWPCK CPQQKPRCPP GVSLVRDGCG CCKICAKQPG EICNEADLCD PHKGLYCDYS VDRPRYETGV CAYLVAVGCE FNQVHYHNGQ VFQPNPLFSC LCVSGAIGCT PLFIPKLAGS HCSGAKGGKK SDQSNCSLEP LLQQLSTSYK TMPAYRNLPL IWKKKCLVQA TKWTPCSRTC GMGISNRVTN ENSNCEMRKE KRLCYIQPCD SN |
| Synonyms | WISP3; PPD; CCN6; LIBC; PPAC |
| Uniprot ID | O95389 |
| Protein RefSeq | NP_003871 |
| mRNA RefSeq | NM_003880 |