Description / anti-mouse VEGF-D monoclonal antibody
VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.
More Information
| Size | 100 µg |
|---|---|
| Source | Rat |
| Isotype | IgG |
| Clone Nr. | (#8C35) |
| Species Reactivity | Mouse |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant mouse VEGF-D recombinant protein). The IgG2 fraction of culture supernatant was purified by Protein G affinity chromatography. |
| Antigen | recombinant mouse VEGF-D |
| Application | IHC, WB |
| Synonyms | vascular endothelial growth factor D; Figf; Vegfd; VEGF-D; AI325264 |
| Uniprot ID | O35251 |
| Protein RefSeq | NP_113949.1 |
| mRNA RefSeq | NM_031761.1 |