Description / human VAP-1 protein
VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaqui oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. VAP-1 can catalyze the oxidative deamination of low molecular weight amines, and plays an important role in the migration of lymphocytes to inflamed tissue. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor.
More Information
| Size | 2 µg |
|---|---|
| Source | CHO cells |
| Biological Activity | Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity >16 pMoles/min/µg of VAP-1. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analysis |
| Length [aa] | 737 |
| Molecular Weight | 81.8 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | GRGGDGGEPS QLPHCPSVSP SAQPWTHPGQ SQLFADLSRE ELTAVMRFLT QRLGPGLVDA AQARPSDNCV FSVELQLPPK AAALAHLDRG SPPPAREALA IVFFGRQPQP NVSELVVGPL PHPSYMRDVT VERHGGPLPY HRRPVLFQEY LDIDQMIFNR ELPQASGLLH HCCFYKHRGR NLVTMTTAPR GLQSGDRATW FGLYYNISGA GFFLHHVGLE LLVNHKALDP AR |
| Synonyms | AOC3; HPAO; SSAO; VAP1; VAP-1 |
| Uniprot ID | Q16853 |
| Protein RefSeq | NP_003725.1 |
| mRNA RefSeq | NM_003734.3 |