Description / anti-human TROP-2 monoclonal antibody
Human TROP-2, also called tumor associated calcium signal transducer 2 (TACSTD2), gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It is related to EpCAM, also called TROP-1, gp40 and KSA. A study of these two genes suggests that TROP-2 was generated through the retropositioning of the EpCAM gene. TROP-2 and EpCAM share approximately 49% amino acid sequence identity and approximately 67% similarity. Mature human and mouse TROP-2 share 80% amino acid identity.
More Information
| Size | 50 µg |
|---|---|
| Source | Mouse |
| Isotype | IgG2A |
| Clone Nr. | (#49D6) |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. |
| Stability and Storage | Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity. |
| Preparation | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human TROP-2 recombinant protein. |
| Antigen | human recombinant TROP-2 |
| Application | WB, FC |
| Synonyms | TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1 |
| Uniprot ID | P09758 |
| Protein RefSeq | NP_002344 |
| mRNA RefSeq | NM_002353 |