Description / human TRAIL R-1/DR4, soluble protein
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
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| Size | 10 µg |
|---|---|
| Source | E. coli |
| Biological Activity | Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 µg/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 215 |
| Molecular Weight | 22.7 kDa |
| Species Reactivity | Human |
| Formulation | lyophilized |
| Protein Sequence | MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN |
| Synonyms | TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1 |
| Uniprot ID | O00220 |
| Protein RefSeq | NP_003835.3 |
| mRNA RefSeq | NM_003844.3 |